Kaizer Chiefs Football Club (often known as Chiefs) are a South African professional football club based in Naturena, Johannesburg South, that plays in the Premier Soccer League. The team is nicknamed AmaKhosi, which means "Lords" or "Chiefs" in Zulu, and the Phefeni Glamour Boys. Chiefs have won 13 league titles (four in the PSL era) and over 78 club trophies. As a result, they hold the most trophies amongst all clubs in South Africa and are the most successful team in South African football history since the start of the top flight in 1970. They are the most supported club in the country, drawing an average home attendance of 16,144 in the 2019–20 season, the highest in the league. The team plays its home matches at the 94,797-capacity FNB Stadium.

The team has a strong local rivalry with Orlando Pirates, a fellow Soweto team that Chiefs founder Kaizer Motaung played for in his early playing career. Famous players who donned the black-and-gold jersey in the past include former national team captains Neil Tovey and Lucas Radebe as well as Patrick Ntsoelengoe, Gary Bailey, John "Shoes" Moshoeu, Shaun Bartlett, Steve Komphela, Siyabonga Nomvete, and Doctor Khumalo.

The Kaizer Chiefs were banned by the African Football (CAF) from competing in African club competitions until 2009 after their abrupt withdrawal from the 2005 CAF Confederation Cup. This was the second time in four years that Chiefs had been penalized by CAF for refusal to participate in a competition.

It is the most supported team in sub-Saharan Africa. Kaizer Chiefs had a support base of over 16,000,000 at the turn of the century. Today, it is estimated at approximately 40,000,000 fans across Southern Africa, the majority of the fanbase in South Africa and neighbouring countries. In January 2023, Kaizer Chiefs celebrated their 53rd anniversary.

Kaiser Chiefs, the British indie rock/britpop band, was named after the club because Lucas Radebe, a former player of Kaizer Chiefs, captained Leeds United, the team that the band members all supported.